Set in 1947, Seklusyon follows newly ordained deacons who are sent to a secluded monastery to undergo a final week of isolation (seclusion) to protect themselves from the temptations of evil before becoming priests. Their spiritual journey is disrupted by the arrival of a mysterious child named Anghela, who claims to have healing powers but may be hiding a dark secret. As strange events unfold, the deacons must confront their sins and question their faith.